Rehman Nahid, Pandey Anjana
Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad (MNNITA), Allahabad, India.
Curr Protein Pept Sci. 2025;26(5):321-333. doi: 10.2174/0113892037311290240930054913.
The diagnosis of intestinal injury remains a challenge as it is rare in occurrence and transpires in multiple traumatized patients. The deferred finding of injury of intestines upsurges multiple risks such as septicemia, numerous organ failures as well as mortality. In this review, we corroborate with the goals of proposing surrogate biomarkers that consent to the measurement of the permeability of intestines more effortlessly. The expression of intestinal fatty acid binding protein (I-FABP) is exclusive in the intestine and has been reported to release extracellularly upon damage caused to tissues. This work focuses on evaluating the legitimacy of I-FABP as an initial biomarker to distinguish abdominal damage predominantly from an injury to the intestine.
肠道损伤的诊断仍然是一项挑战，因为其发生率很低，且多发生于多处创伤患者。肠道损伤的延迟发现会增加多种风险，如败血症、多器官功能衰竭以及死亡风险。在本综述中，我们认同提出替代生物标志物的目标，这些生物标志物应能更轻松地实现对肠道通透性的测量。肠道脂肪酸结合蛋白（I-FABP）在肠道中具有独特表达，据报道，在组织受损时它会释放到细胞外。这项工作的重点是评估I-FABP作为一种初始生物标志物来主要区分腹部损伤与肠道损伤的合理性。
