欧洲分子生物学组织研讨会——“分子与细胞老年学”：1999年9月18日至22日于瑞士塞皮亚诺举行。

EMBO workshop--"Molecular and Cellular Gerontology": Sepiano/Switzerland, September 18-22, 1999.

作者信息

Jansen-Dürr P, Wick G

机构信息

Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria.

出版信息

Exp Gerontol. 2000 Mar;35(2):251-7. doi: 10.1016/s0531-5565(00)00082-6.

DOI:10.1016/s0531-5565(00)00082-6

PMID:10858083

Abstract

The EMBO Workshop "Molecular and Cellular Gerontology" provided a comprehensive analysis of recent developments in experimental gerontology. Various animal models for aging were presented. The focus of the conference was on the role of oxidative stress in aging at the cellular and organismal level. Evolution of aging was another topic discussed in the course of the meeting. Another focal point of the meeting was on age-related changes in cellular repair systems, in particular DNA repair and protein repair. Emphasis was also placed on the role of mitochondrial function and mitochondrial DNA mutations in the aging process. These molecular approaches were complemented by a session on age-related diseases, including aging of the immune system, cardiovascular disease and Alzheimer's disease.

摘要

欧洲分子生物学组织（EMBO）研讨会“分子与细胞老年学”对实验老年学的最新进展进行了全面分析。会上展示了各种衰老动物模型。会议重点关注氧化应激在细胞和机体水平衰老过程中的作用。衰老的进化是会议期间讨论的另一个话题。会议的另一个焦点是细胞修复系统的年龄相关变化，特别是DNA修复和蛋白质修复。线粒体功能和线粒体DNA突变在衰老过程中的作用也受到了重视。这些分子方法辅以一场关于年龄相关疾病的会议，包括免疫系统衰老、心血管疾病和阿尔茨海默病。