[晚期宫颈癌治疗中的预后因素。一项回顾性研究]

[Prognostic factors in the treatment of advanced cervical cancer. A retrospective study].

作者信息

Sacco M, Tessa M, Rampino M, Ragona R, Airaldi C, Nassisi D, Rondi N, Gatti M, Garnero G, Rotta P

机构信息

Dipartimento di Discipline Medico-Chirurgiche, Università degli Studi, Torino.

出版信息

Minerva Med. 2000 Jan-Feb;91(1-2):17-30.

PMID:10858729

Abstract

BACKGROUND

The value of prognostic factors in patients with advanced cervix carcinoma treated by radiotherapy was assessed in a retrospective study.

METHODS

From January 1977 through December 1990, 261 patients (average age 60 years) were treated at the Radiotherapy Department of the University of Turin. Distribution by stage was: 142 T2b (54%), 8 T3a (3%), 98 T3b (38%) and 13 T4 (5%). 83% of the patients underwent radiotherapy alone; the total dose was 45-88 Gy in 91 patients (42%) with poor clinical conditions, 60-75 Gy in 121 (56%) and 75-80 Gy in 5 cases. 17% of the patients was treated by surgery combined with radiotherapy. The median follow-up was 50 months (minimum 2, maximum 177 months).

RESULTS

The 5-year NED survival and local control were 42% (52% for T2b, 33% for T3 and 15% for T4). The severe (G3-G4) complication rate was very low (1.9%).

CONCLUSION

In our series, the prognostic factors which significantly influenced survival in the uni-variate analysis were: advanced T stage, contemporary infiltration of parametrium and vagina, nodal status, non squamous neoplasm, younger age and the absence of brachytherapy in the radiotherapy alone protocol.

摘要

背景

在一项回顾性研究中评估了放疗对晚期宫颈癌患者预后因素的价值。

方法

1977年1月至1990年12月期间，261例患者（平均年龄60岁）在都灵大学放射治疗科接受治疗。按分期分布为：142例T2b期（54%），8例T3a期（3%），98例T3b期（38%）和13例T4期（5%）。83%的患者仅接受放疗；91例（42%）临床状况较差的患者总剂量为45 - 88 Gy，121例（56%）患者为60 - 75 Gy，5例患者为75 - 80 Gy。17%的患者接受手术联合放疗。中位随访时间为50个月（最短2个月，最长177个月）。