Davezac N, Ducommun B, Baldin V
Laboratoire de biologie cellulaire et moléculaire du contrôle de la prolifération, université Paul-Sabatier, CNRS UMR 5088, Toulouse, France.
Pathol Biol (Paris). 2000 Apr;48(3):182-9.
Progression in cell cycle is controlled by CDKs (cyclin dependent kinases) and their cyclins regulatory subunits. In mammalian cells, three dual specificity phosphatases called CDC25 activate CDKs/cyclin complexes. The activity of CDC25 is regulated by phosphorylation and dephosphorylation events. CDC25 phosphatases also participate in cell cycle checkpoints activated in response to DNA damage. Two members of this family, CDC25 A and CDC25 B, have oncogenic properties, and their overexpression has been detected in various types of tumors.
细胞周期的进程由细胞周期蛋白依赖性激酶（CDK）及其细胞周期蛋白调节亚基控制。在哺乳动物细胞中，三种称为细胞分裂周期蛋白25（CDC25）的双重特异性磷酸酶激活CDK/细胞周期蛋白复合物。CDC25的活性受磷酸化和去磷酸化事件调节。CDC25磷酸酶也参与响应DNA损伤而激活的细胞周期检查点。该家族的两个成员，CDC25 A和CDC25 B，具有致癌特性，并且已在各种类型的肿瘤中检测到它们的过表达。
