Eriksen J G, Bastholt L, Krogdahl A S, Hansen O, Joergensen K E
Department of Oncology, Odense University Hospital, Denmark.
Acta Oncol. 2000;39(2):231-5. doi: 10.1080/028418600430833.
A retrospective review was conducted on 13 patients with esthesioneuroblastoma (ENB), treated at our institution from 1977 to 1997. According to the Kadish classification, one patient was in stage A, 5 patients were classified as stage B and 7 patients were in stage C. Five-year disease-specific survival was found to be 51%. Forty-six percent of the patients experienced relapse and despite intensive salvage therapy, median survival after recurrences was only 12 months. This indicates the need for good primary control in local as well as distant disease. The role of pre- versus postoperative radiotherapy to secure good local control is discussed and compared with the literature, and treatment guidelines are proposed. The tumours were graded according to the Hyams' classification and its importance as a prognostic factor is briefly discussed.
对1977年至1997年期间在我们机构接受治疗的13例嗅神经母细胞瘤（ENB）患者进行了回顾性研究。根据卡迪什分类，1例患者为A期，5例患者分类为B期，7例患者为C期。发现5年疾病特异性生存率为51%。46%的患者出现复发，尽管进行了强化挽救治疗，但复发后的中位生存期仅为12个月。这表明需要对局部和远处疾病进行良好的初始控制。讨论了术前与术后放疗在确保良好局部控制方面的作用，并与文献进行了比较，同时提出了治疗指南。根据海姆斯分类法对肿瘤进行分级，并简要讨论了其作为预后因素的重要性。
