Drago L, Fassina M C, Mombelli B, De Vecchi E, Lombardi A, Gismondo M R
Laboratory of Clinical Microbiology, Department of Preclinical Science, L.I.T.A. Vialba, Milan, Italy.
Chemotherapy. 2000 Jul-Aug;46(4):275-81. doi: 10.1159/000007299.
Thiamphenicol glycinate (TG) and its derivative thiamphenicol glycinate N-acetylcysteinate (TGA) could be a valid therapeutic option in the treatment of respiratory tract infections.
Time-kill curves of TG and TGA and pulmonary clearance in Haemophilus influenzae infected guinea pigs were compared with those of clarithromycin, ceftriaxone and amoxicillin plus clavulanic acid.
The bacterial activities of the tested antibiotics were comparable. When compared to the control group, lung bacterial counts were significantly lower for the TGA group at 3 h vs. controls, while for the other treatments, significant decreases were recorded after 6 h. All drugs showed a log count of <2.0 at 24 h with respect to the control while at 48 h all groups demonstrated a log count of <2.0.
Although the in vitro activity of the tested drugs evaluated by time-kill curves seemed comparable, some pharmacokinetic and pharmacodynamic characteristics of TGA contribute to improving the resolution of the infective process.
甘氨酸氯霉素（TG）及其衍生物甘氨酸氯霉素N - 乙酰半胱氨酸盐（TGA）可能是治疗呼吸道感染的有效治疗选择。
将TG和TGA的时间杀菌曲线以及在感染流感嗜血杆菌的豚鼠中的肺部清除情况与克拉霉素、头孢曲松和阿莫西林加克拉维酸进行比较。
所测试抗生素的细菌活性相当。与对照组相比，TGA组在3小时时肺部细菌计数显著低于对照组，而其他治疗组在6小时后记录到显著下降。所有药物在24小时相对于对照组的对数计数均<2.0，而在48小时时所有组的对数计数均<2.0。
尽管通过时间杀菌曲线评估的所测试药物的体外活性似乎相当，但TGA的一些药代动力学和药效学特征有助于提高感染过程的消退。
