Greenough A
Dept of Child Health, King's College Hospital, London, UK.
Semin Neonatol. 2000 May;5(2):119-26. doi: 10.1053/siny.1999.0006.
Chronic respiratory morbidity is a common outcome of very premature birth. Infants who are chronically oxygen dependent with an abnormal chest radiograph are described as suffering from chronic lung disease (CLD), and those with the worst abnormalities diagnosed as having bronchopulmonary dysplasia. CLD infants are very likely to be readmitted to hospital during infancy, particularly during a respiratory syncytial virus (RSV) epidemic. Very low birthweight, prematurity and CLD are associated with recurrent respiratory symptoms and lung function abnormalities during the preschool years. These problems are detected even in adolescents who were chronically oxygen dependent after premature birth. Further research to identify effective preventative strategies is urgently required.
慢性呼吸系统疾病是极早产的常见后果。胸部X光片异常且长期依赖氧气的婴儿被描述为患有慢性肺病(CLD),而那些异常情况最严重的被诊断为支气管肺发育不良。CLD婴儿在婴儿期很可能再次入院,尤其是在呼吸道合胞病毒(RSV)流行期间。极低出生体重、早产和CLD与学龄前反复出现的呼吸道症状和肺功能异常有关。即使在早产后长期依赖氧气的青少年中也能检测到这些问题。迫切需要进一步研究以确定有效的预防策略。