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[Acute necrotizing hepatitis: an unusual side effect of oral anticoagulants].

作者信息

Capoferri M, Realini S, Balestra B

机构信息

Reparto di Medicina Interna e Gastroenterologia, Ospedale Regionale della Beata Vergine, Mendrisio.

出版信息

Praxis (Bern 1994). 2000 May 18;89(21):929-32.

PMID:10859983
Abstract

We report the case of a severe relapsing phenprocoumon-induced hepatitis. The first episode of hepatitis was thought to be caused by another drug (Verapamil). The anticoagulation with Phenprocoumon was therefore continued after healing of liver inflammation. The relapse typically developed after a shorter exposition-time supporting the hypothesis of an allergic etiology. Fortunately we didn't find any cross-reaction between Phenprocoumon and Acenocoumarol. The patient could thus be anticoagulated orally without complications. If long term anticoagulation is absolutely essential, it is reasonable to prescribe a different Coumarin-derivate. In the case of a cross-reaction, the therapy should be continued with low-molecular weight heparin.

摘要

相似文献

1
[Acute necrotizing hepatitis: an unusual side effect of oral anticoagulants].
Praxis (Bern 1994). 2000 May 18;89(21):929-32.
2
[Phenprocoumon-induced necrotizing hepatitis].
Dtsch Med Wochenschr. 2001 Apr 20;126(16):457-9. doi: 10.1055/s-2001-12889.
3
[Recurrent hepatitis in oral anticoagulation: coumarin-induced hepatitis].
Ther Umsch. 1999 Sep;56(9):513-5. doi: 10.1024/0040-5930.56.9.513.
4
[Phenprocoumon-associated necrotizing hepatitis].
Dtsch Med Wochenschr. 2001 Sep 21;126(38):1060. doi: 10.1055/s-2001-17308.
5
[Phenprocoumon-induced necrotizing hepatitis].
Dtsch Med Wochenschr. 1995 Nov 3;120(44):1529-30.
6
[Phenprocoumon-induced cholestatic hepatitis].苯丙香豆素所致胆汁淤积性肝炎
Dtsch Med Wochenschr. 1995 Nov 3;120(44):1507-10. doi: 10.1055/s-2008-1055506.
7
Idiosyncratic drug allergic phenprocoumon-induced hepatitis with subacute liver failure initially misdiagnosed as autoimmune hepatitis.特异性药物过敏苯丙香豆素诱发的肝炎伴亚急性肝衰竭，最初被误诊为自身免疫性肝炎。
Scand J Gastroenterol. 2001 Jul;36(7):780-3. doi: 10.1080/003655201300192076.
8
Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure.
J Hepatol. 2004 Jul;41(1):67-74. doi: 10.1016/j.jhep.2004.03.010.
9
[Acute liver failure caused by phenprocoumon -- three case reports].[苯丙香豆素所致急性肝衰竭——三例报告]
Z Gastroenterol. 2004 Sep;42(9):1055-8. doi: 10.1055/s-2004-813320.
10
Drug-induced hepatitis: a rare complication of oral anticoagulants.
J Hepatol. 1994 Sep;21(3):447-9. doi: 10.1016/s0168-8278(05)80326-5.

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1
[Role of vitamin K antagonists from a hepatologist's point of view].
Herz. 2012 Jun;37(4):395-401. doi: 10.1007/s00059-012-3620-2.
2
Evidence for immunological (allergic) mechanisms in a subgroup of patients with phenprocoumon-induced liver disease.在苯丙香豆素诱导的肝损伤患者亚组中存在免疫（过敏）机制的证据。
Eur J Clin Pharmacol. 2009 Dec;65(12):1195-201. doi: 10.1007/s00228-009-0705-9.