Toft P, Felding M, Tønnesen E K
Arhus Universitetshospital, Arhus Kommunehospital, anaestesiologisk-intensiv afdeling N.
Ugeskr Laeger. 2000 May 15;162(20):2868-71.
The development of computerized machines with a simple user-friendly interface to perform continuous venovenous hemodiafiltration (CVVHDF) has resulted in a break-through of CVVHDF in the treatment of acute renal failure (ARF) in Danish intensive care units. During CVVHDF the blood is submitted to a combination of dialysis and ultrafiltration. In contrast to intermittent haemodialysis (HD), CVVHDF can be used in critically ill patients with unstable circulation. Biocompatible membranes are used. During treatment with CVVHDF, cytokines are removed from the blood partly by ultrafiltration, partly by adsorption to the filter. The clinical importance of this is not yet known. Patients with ARF treated with CVVHDF seem to be more likely to show renal recovery than those treated with HD. There are few prospective investigations of the effect of CVVHDF on mortality, but all comparisons of CVVHDF with HD indicate a trend in favor of CVVHDF.
具有简单用户友好界面的计算机化机器用于进行连续性静脉-静脉血液透析滤过（CVVHDF），这使得CVVHDF在丹麦重症监护病房治疗急性肾衰竭（ARF）方面取得了突破。在CVVHDF过程中，血液要接受透析和超滤的联合作用。与间歇性血液透析（HD）不同，CVVHDF可用于循环不稳定的危重病患者。使用的是生物相容性膜。在CVVHDF治疗期间，细胞因子部分通过超滤、部分通过吸附到滤器上而从血液中清除。其临床重要性尚不清楚。接受CVVHDF治疗的ARF患者似乎比接受HD治疗的患者更有可能实现肾脏恢复。关于CVVHDF对死亡率影响的前瞻性研究很少，但所有CVVHDF与HD的比较都表明有倾向于CVVHDF的趋势。
