Auger A P, Tetel M J, McCarthy M M
Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA.
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7551-5. doi: 10.1073/pnas.97.13.7551.
Steroid hormone action during brain development exerts profound effects on reproductive physiology and behavior that last into adulthood. A variety of in vitro studies indicate that steroid receptors require nuclear receptor coactivators for efficient transcriptional activity. To determine the functional significance of the nuclear receptor coactivator SRC-1 in developing brain, we investigated the consequence of reducing SRC-1 protein during sexual differentiation of the brain. We report that reducing SRC-1 protein interferes with the defeminizing actions of estrogen in neonatal rat brain. Our data indicate that SRC-1 protein expression is critically involved in the hormone-dependent development of normal male reproductive behavior and brain morphology.
类固醇激素在大脑发育过程中的作用对生殖生理和行为产生深远影响,这些影响会持续到成年期。各种体外研究表明,类固醇受体需要核受体共激活因子才能实现有效的转录活性。为了确定核受体共激活因子SRC-1在发育中的大脑中的功能意义,我们研究了在大脑性别分化过程中降低SRC-1蛋白的后果。我们报告说,降低SRC-1蛋白会干扰雌激素在新生大鼠大脑中的去雌性化作用。我们的数据表明,SRC-1蛋白表达在正常雄性生殖行为和大脑形态的激素依赖性发育中起着关键作用。