谷氨酸和红藻氨酸对龙虾肌纤维和青蛙脊髓作用的比较研究。
A comparative study of the effects of glutamate and kainate on the lobster muscle fibre and the frog spinal cord.
作者信息
Constanti A, Nistri A
出版信息
Br J Pharmacol. 1976 Jul;57(3):359-68. doi: 10.1111/j.1476-5381.1976.tb07674.x.
Abstract
1 The depolarizing actions of glutamate and its conformationally restricted analogue kainate were investigated on the lobster muscle fibre and the frog spinal cord using intracellular and extracellular recordings, respectively. 2 Bath-applied kainate was less potent than glutamate on the lobster fibre but more potent on the frog cord. From the log-log transformation of dose-response curves it was proposed that more than one glutamate molecule was necessary to activate both the lobster and the frog receptor sites. In the frog, at least three kainate molecules were thought to be required for receptor activation. 3 The ionic dependence of glutamate and kainate responses appeared different for the two tissues. 4 Some possible explanations of the differential tissue sensitivity to kainate are discussed.
摘要
- 分别使用细胞内和细胞外记录方法，研究了谷氨酸及其构象受限类似物海藻酸盐对龙虾肌肉纤维和青蛙脊髓的去极化作用。2. 浴用海藻酸盐对龙虾纤维的作用比谷氨酸弱，但对青蛙脊髓的作用更强。根据剂量反应曲线的对数-对数转换，有人提出激活龙虾和青蛙的受体位点需要不止一个谷氨酸分子。在青蛙中，至少需要三个海藻酸盐分子才能激活受体。3. 谷氨酸和海藻酸盐反应的离子依赖性在两种组织中似乎有所不同。4. 讨论了对海藻酸盐组织敏感性差异的一些可能解释。
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