Bostwick D G, Ramnani D, Qian J
Bostwick Laboratories, Richmond, Virginia 23226, USA.
Prostate. 2000 Jun 1;43(4):286-94. doi: 10.1002/1097-0045(20000601)43:4<286::aid-pros8>3.0.co;2-0.
Numerous animal models of preinvasive prostate cancer have been described in the past decade. Differences among models account for their variable applicability for answering specific research questions. The dog is the only known nonhuman spontaneous animal model of prostate cancer, but numerous transgenic and therapy-induced models have been generated in mice and rats. This report summarizes existing models of prostatic intraepithelial neoplasia and their relevance for the study of human prostate cancer.
在过去十年中，已经描述了许多前列腺癌原位癌的动物模型。模型之间的差异导致它们在回答特定研究问题时适用性各不相同。狗是已知唯一的非人类前列腺癌自发动物模型，但在小鼠和大鼠中已经产生了许多转基因和治疗诱导模型。本报告总结了现有的前列腺上皮内瘤变模型及其与人类前列腺癌研究的相关性。
