Tabata Y, Hibi S, Maruyama-Tabata H, Tsunamoto K, Todo S, Sawada T, Okamura T, Kawa-Ha K, Imashuku S
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Am J Hematol. 2000 Jul;64(3):203-5. doi: 10.1002/1096-8652(200007)64:3<203::aid-ajh11>3.0.co;2-5.
A 28-month-old girl with acute lymphoblastic leukemia (ALL) showing a t(4;11)(q21;q23) karyotype successfully underwent allogeneic bone marrow transplantation (BMT) at relapse. The chimeric MLL-AF4 message on her bone marrow (BM) specimens, examined by reverse transcriptase-polymerase chain reaction, was detectable at diagnosis, relapse, and just before BMT but became undetectable following BMT. She has since maintained complete remission. This observation suggests that detection of the chimeric message in BM may be useful to predict clinical outcome in patients with t(4;11) ALL.
一名28个月大的急性淋巴细胞白血病（ALL）女童，核型为t(4;11)(q21;q23)，复发时成功接受了异基因骨髓移植（BMT）。通过逆转录聚合酶链反应检测其骨髓（BM）标本中的嵌合MLL-AF4信息，在诊断、复发时以及BMT前均可检测到，但在BMT后变得无法检测到。此后她一直保持完全缓解。这一观察结果表明，检测BM中的嵌合信息可能有助于预测t(4;11) ALL患者的临床结局。
