Zappacosta B, Persichilli S, Giardina B, De Sole P
Istituto di Chimica e Chimica Clinica and CNR Centro Chimica dei Recettori Università Cattolica del Sacro Cuore, Rome, Italy.
Luminescence. 2000 May-Jun;15(3):165-8. doi: 10.1002/1522-7243(200005/06)15:3<165::AID-BIO582>3.0.CO;2-X.
Cigarette smoke induces a vast cohort of deleterious effects on biological structures. In the present paper, the effect of aqueous extract of cigarette smoke on the activity of polymorphonuclear leukocytes was studied. Although the aqueous extract of cigarette smoke inhibits the luminol oxidation catalysed by horseradish peroxidase, it strongly interacts with polymorphonuclear leukocytes and inhibits their phorbol-induced chemiluminescence in the presence of either luminol or lucigenin. The results indicate that at least some of the components of the aqueous extract of cigarette smoke may strongly interfere with polymorphonuclear cells, contributing to the deleterious effects of smoke products.
香烟烟雾对生物结构会产生大量有害影响。在本文中，研究了香烟烟雾水提取物对多形核白细胞活性的影响。虽然香烟烟雾水提取物会抑制辣根过氧化物酶催化的鲁米诺氧化反应，但它会与多形核白细胞强烈相互作用，并在存在鲁米诺或光泽精的情况下抑制其佛波醇诱导的化学发光。结果表明，香烟烟雾水提取物的至少某些成分可能会强烈干扰多形核细胞，从而导致烟雾产物产生有害影响。
