North M J, Campbell A J
J Gen Microbiol. 1976 Sep;96(1):77-85. doi: 10.1099/00221287-96-1-77.
epsilon-Aminocaproic acid (EACA) inhibited the development of Dictyostelium discoideum strain AX2 after the aggregation stage. Biochemical changes that occurred early in development (loss of cellular protein, RNA and carbohydrate; increase in the specific activity of N-acetylglucosaminidase, alpha-mannosidase, threonine deaminase and leucine aminopeptidase) were not affected by concentrations of EACA which blocked development; but biochemical changes that occurred later (synthesis of carbohydrate, increase in the specific activity of UDP-glucose pyrophosphorylase) were inhibited. Spores from fruiting bodies formed in the presence of low concentrations of EACA were larger, more spherical and less able to survive heat treatment than spores from fruiting bodies of control (no EACA) cells.
ε-氨基己酸（EACA）在聚集期后抑制了盘基网柄菌AX2菌株的发育。发育早期发生的生化变化（细胞蛋白质、RNA和碳水化合物的损失；N-乙酰葡糖胺酶、α-甘露糖苷酶、苏氨酸脱氨酶和亮氨酸氨肽酶比活性的增加）不受阻断发育的EACA浓度的影响；但后期发生的生化变化（碳水化合物的合成、UDP-葡萄糖焦磷酸化酶比活性的增加）受到抑制。在低浓度EACA存在下形成的子实体中的孢子比对照（无EACA）细胞子实体中的孢子更大、更呈球形且耐热性更差。
