实体瘤的大剂量甲氨蝶呤治疗：与临床毒性相关的观察结果
High dose methotrexate therapy of solid tumors: observations relating to clinical toxicity.
作者信息
Isacoff W H, Townsend C M, Eiber F R, Forster T, Morton D L, Block J B
出版信息
Med Pediatr Oncol. 1976;2(3):319-25. doi: 10.1002/mpo.2950020313.
PMID:1086423
Abstract
In clinical studies performed during 111 infusions of high dose methotrexate (MTX) we have evolved a clinical and laboratory protocol which permits such therapy without prohibitive risk to the patient. The plasma MTX data obtained indicate that pharmacokinetic disposition is dose related during these infusions and that such data are useful in identifying patients at risk from serious toxicity.
摘要
在针对111次大剂量甲氨蝶呤（MTX）输注进行的临床研究中，我们制定了一项临床和实验室方案，该方案可使这种治疗对患者不构成过高风险。所获得的血浆MTX数据表明，在这些输注过程中，药代动力学处置与剂量相关，并且这些数据有助于识别有严重毒性风险的患者。
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