Tam V H, Moore G E, Triller D M, Briceland L L
Albany College of Pharmacy, New York, USA.
J Intraven Nurs. 1999 Nov-Dec;22(6):336-42.
Vancomycin is a glycopeptide antibiotic commonly used in the treatment of gram-positive bacterial infections. With the rising prevalence of resistant gram-positive bacterial infections in healthcare institutions and the advent of attempts to curb escalating medical cost, vancomycin is being used with increasing frequency in the homecare setting for infection management. In view of its variability in pharmacokinetics and the potential for toxicities, serum concentrations often are measured. This article reviews the pharmacology of vancomycin and suggests a practical approach to serum concentration monitoring in homecare.
万古霉素是一种糖肽类抗生素，常用于治疗革兰氏阳性菌感染。随着医疗机构中耐革兰氏阳性菌感染的患病率不断上升，以及控制医疗成本不断攀升的尝试出现，万古霉素在家庭护理环境中用于感染管理的频率越来越高。鉴于其药代动力学的变异性和毒性可能性，通常会测量血清浓度。本文综述了万古霉素的药理学，并提出了一种在家庭护理中监测血清浓度的实用方法。
