Goodpaster B H, Thaete F L, Kelley D E
Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA. bgood+@pitt.edu
Ann N Y Acad Sci. 2000 May;904:18-24. doi: 10.1111/j.1749-6632.2000.tb06416.x.
Computed tomography (CT) can yield quantitative imaging data from detailed maps of linear attenuation coefficients within tissue. The attenuation characteristics of skeletal muscle and adipose tissue can be quantified in vivo to provide information about the composition of skeletal muscle and the distribution of adipose tissue within muscle. Several studies have taken advantage of this utility to quantify skeletal muscle composition and fatty infiltration of muscle, in particular to quantify the attenuation characteristics of muscle as a marker of its lipid content. In this manner we found that the mean muscle attenuation of skeletal muscle reflects an increase in its fat content in obesity, and that this regional body composition parameter is strongly related to insulin-resistant glucose metabolism. In addition, muscle composition and adipose tissue distribution within muscle may be altered with clinical weight-loss interventions. CT may also provide important information about the changes in muscle mass and composition with aging and disease, which may, in turn, affect the muscle's function. In summary, CT can provide important quantitative data on the composition of muscle, and the distribution of adipose tissue within it, and this may be important in examining the relationships among skeletal muscle metabolism, lipid accumulation within muscle, and muscle function.
计算机断层扫描（CT）能够从组织内线性衰减系数的详细图谱中获取定量成像数据。骨骼肌和脂肪组织的衰减特性可在体内进行量化，以提供有关骨骼肌组成和肌肉内脂肪组织分布的信息。多项研究利用了这一特性来量化骨骼肌组成和肌肉的脂肪浸润，特别是将肌肉的衰减特性量化为其脂质含量的标志物。通过这种方式，我们发现肥胖时骨骼肌的平均肌肉衰减反映了其脂肪含量的增加，并且这一局部身体组成参数与胰岛素抵抗性葡萄糖代谢密切相关。此外，临床减肥干预可能会改变肌肉组成和肌肉内脂肪组织的分布。CT还可提供有关随着衰老和疾病肌肉质量和组成变化的重要信息，而这些变化反过来可能会影响肌肉功能。总之，CT能够提供有关肌肉组成及其内脂肪组织分布的重要定量数据，这对于研究骨骼肌代谢、肌肉内脂质积累和肌肉功能之间的关系可能具有重要意义。
