Bull World Health Organ. 1976;53(4):425-33.
The Memorandum reviews the considerable progress that has been made in research on the chemotherapy of leprosy during the last 10-15 years, as a result of which it is now possible to study the same topics in leprosy as are studied in other bacterial diseases. Thus drugs have been screened in mice for their activity against Mycobacterium leprae. Those that have been found to have the greatest activity against M. leprae at acceptable dosages-dapsone, rifampicin, and clofazimine-have been characterized in terms of the minimal effective dosage and rate of bacterial kill. Similarly, their pharmacokinetics in man and in certain animals have been defined. The theoretical basis for drug trials in leprosy patients is discussed in terms of the number of viable and the number of dead M. leprae that remain at various stages of therapy.
本备忘录回顾了过去10至15年中麻风病化疗研究取得的重大进展。因此，现在可以像研究其他细菌性疾病一样研究麻风病的相同课题。于是在小鼠身上筛选了药物对麻风分枝杆菌的活性。已发现那些在可接受剂量下对麻风分枝杆菌活性最高的药物——氨苯砜、利福平及氯法齐明——在最小有效剂量和细菌杀灭率方面得到了表征。同样，它们在人体和某些动物体内的药代动力学也已明确。根据治疗不同阶段存活和死亡的麻风分枝杆菌数量，讨论了麻风病患者药物试验的理论基础。
