路易体痴呆患者帕金森症的一年随访
One year follow-up of parkinsonism in dementia with Lewy bodies.
作者信息
Ballard C, O'Brien J, Swann A, Neill D, Lantos P, Holmes C, Burn D, Ince P, Perry R, McKeith I
机构信息
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK.
出版信息
Dement Geriatr Cogn Disord. 2000 Jul-Aug;11(4):219-22. doi: 10.1159/000017240.
The progression of parkinsonism over 1 year was evaluated in a prospective cohort of patients (n = 338), suffering from dementia with Lewy bodies (DLB), Alzheimer's disease (AD) or vascular dementia (VaD). Parkinsonism was assessed using the modified Unified Parkinson's Disease Rating Scale. Significant parkinsonism was significantly commoner in DLB sufferers (71%) than amongst patients with AD (7%) or VaD (10%). DLB patients with established parkinsonism had an annual increase in severity of 9%, but progression was more rapid (49% in 1 year) in patients with early parkinsonism. Parkinsonism was frequent at all severities in DLB patients, but usually only present in other dementias when MMSE <10.
在一组前瞻性队列患者（n = 338）中评估了帕金森症在1年中的进展情况，这些患者患有路易体痴呆（DLB）、阿尔茨海默病（AD）或血管性痴呆（VaD）。使用改良的统一帕金森病评定量表评估帕金森症。显著帕金森症在DLB患者中（71%）比AD患者（7%）或VaD患者（10%）更为常见。已确诊帕金森症的DLB患者病情严重程度每年增加9%，但早期帕金森症患者的进展更快（1年内为49%）。DLB患者在所有严重程度下帕金森症都很常见，但在其他痴呆症中通常仅在简易精神状态检查表（MMSE）<10时出现。
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