SprE水平在翻译水平上以一种依赖于σ(S)的方式受到生长阶段的调控。
SprE levels are growth phase regulated in a sigma(S)-dependent manner at the level of translation.
作者信息
Gibson K E, Silhavy T J
机构信息
Department of Molecular Biology, Princeton University, NJ 08544, USA.
出版信息
J Bacteriol. 2000 Jul;182(14):4117-20. doi: 10.1128/JB.182.14.4117-4120.2000.
Abstract
SprE regulates sigma(S) levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels is sigma(S) dependent, altering SprE synthesis at the level of translation. Thus, we demonstrate that SprE and sigma(S) function within a regulatory feedback loop.
摘要
SprE通过促进ClpXP介导的降解来响应营养物质的可利用性，从而调节σ(S)水平。矛盾的是，我们观察到SprE受到类似的调节，在饥饿时优先积累。SprE水平的这种调节依赖于σ(S)，在翻译水平上改变SprE的合成。因此，我们证明SprE和σ(S)在一个调节反馈环中发挥作用。
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