多烯抗生素。VII. 碳-13核磁共振证据表明两性霉素B、制霉菌素A1、四环素A、四环素B、光泽霉素和匹马霉素等多烯抗生素中存在环状半缩酮1,2 。
Polyene antibiotics. VII. Carbon-13 nuclear magnetic resonance evidence for cyclic hemiketals in the polyene antibiotics amphotericin B, nystatin A1, tetrin A, tetrin B, lucensomycin, and pimaricin1,2.
作者信息
Pandey R C, Rinehart K L
出版信息
J Antibiot (Tokyo). 1976 Oct;29(10):1035-42. doi: 10.7164/antibiotics.29.1035.
PMID:1086913
Abstract
Carbon magnetic resonance establishes conclusively that six polyene macrolide antibiotics containing keto groups (the heptaene amphotericin B, the tetraene-diene nystatin A1, and the tetraenes tetrin A, tetrin B, pimaricin, and lucensomycin) exist in the hemiketal form in solution. Their spectra all contain a hemiketal carbon's absorption near 97 ppm but lack a keto carbon's absorption near 210 ppm. The non-polyenic macrolide erythromycin, on the other hand, exists in the keto form.
摘要
碳磁共振确凿地证实，六种含有酮基的多烯大环内酯类抗生素（七烯两性霉素B、四烯-二烯制霉菌素A1以及四烯类的替曲霉素A、替曲霉素B、匹马霉素和光泽霉素）在溶液中以半缩酮形式存在。它们的光谱都在97 ppm附近含有一个半缩酮碳的吸收峰，但在210 ppm附近没有酮碳的吸收峰。另一方面，非多烯大环内酯类红霉素则以酮形式存在。
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