对内皮素说不。
Say NO to ET.
作者信息
Vanhoutte P M
机构信息
Institut de Recherches Internationales Servier, 6, Place des Pléïades, 92415 cedex, Courbevoie, France.
出版信息
J Auton Nerv Syst. 2000 Jul 3;81(1-3):271-7. doi: 10.1016/s0165-1838(00)00126-0.
The endothelial cells release both relaxing [nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF), prostacyclin] and contracting factors [endoperoxides, thromboxane A(2), superoxide anions, endothelin-1 (ET)]. The production of ET is inhibited by NO. The latter also strongly opposes the direct effects of the former on vascular smooth muscle. With aging and vascular disease, the production of enothelial NO declines, and thus ET can be released, act and contribute to the symptoms.
内皮细胞释放舒张因子[一氧化氮（NO）、内皮源性超极化因子（EDHF）、前列环素]和收缩因子[内过氧化物、血栓素A2、超氧阴离子、内皮素-1（ET）]。ET的产生受NO抑制。NO也强烈对抗ET对血管平滑肌的直接作用。随着衰老和血管疾病的发生，内皮NO的产生减少，因此ET得以释放、发挥作用并导致症状出现。
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