Froland S S, Wisloff F, Stavem P
Scand J Haematol. 1976 Oct;17(4):241-50. doi: 10.1111/j.1600-0609.1976.tb01181.x.
Studies of blood lymphocytes from 4 patients with pure red cell aplasia were performed with lymphocyte surface markers, and with various in vitro tests for lymphocyte functions. Pathologically low B-lymphocyte values were found. In contrast, no marked deviation from normals were seen for T-lymphocytes and Fc-receptor-bearing lymphocytes thought largely to represent non-B, non-T-lymphocytes. In 3 patients normal lymphocyte transformation was found with unspecific and specific mitogens, while the DNA-synthesis induced by unspecific mitogens was subnormal in the fourth patients. The lymphocyte-mediated PHA-induced cytotoxicity against target cells in vitro was subnormal in 2 patients, while no depression was seen in antibody-dependent cytotoxicity mediated in vitro by lymphocytes (K-cells). It is concluded that considerable immunological abnormalities are associated with pure red cell aplasia, and the possible significance of this is discussed.
对4例纯红细胞再生障碍性贫血患者的血液淋巴细胞进行了淋巴细胞表面标志物检测以及各种淋巴细胞功能的体外试验。发现B淋巴细胞值在病理上较低。相比之下，T淋巴细胞和主要代表非B、非T淋巴细胞的Fc受体阳性淋巴细胞与正常人无明显差异。3例患者使用非特异性和特异性有丝分裂原时淋巴细胞转化正常，而第4例患者非特异性有丝分裂原诱导的DNA合成低于正常水平。2例患者体外淋巴细胞介导的PHA诱导的对靶细胞的细胞毒性低于正常水平，而淋巴细胞（K细胞）体外介导的抗体依赖性细胞毒性未见降低。结论是纯红细胞再生障碍性贫血伴有相当程度的免疫异常，并讨论了其可能的意义。
