Psychos D N, Voulgari P V, Skopouli F N, Drosos A A, Moutsopoulos H M
Department of Internal Medicine, Medical School, University of Ioannina, Greece.
Clin Rheumatol. 2000;19(3):212-6. doi: 10.1007/s100670050159.
Erythema nodosum (EN) is a cutaneous reaction consisting of inflammatory, tender nodular lesions and is associated with a wide variety of disease processes. The aim of our study was to investigate the frequency of different aetiologies of EN. One hundred and thirty-two EN patients were investigated in a prospective study during the period 1984-1990. The evaluation of all patients began with a medical and family history and completed with a thorough physical examination and detailed laboratory and immunological work-up. In addition, various diagnostic procedures were performed where and when indicated. One hundred and ten patients (83%) were women. Their mean age was 41.0+/-14.0 years, range 18-79 years. In 35% the cause of EN was not found. Sarcoidosis was revealed in 28% of the patients, infections in 17.3% and tuberculosis in 1.5%. Other aetiologic factors were Adamantiadis-Behçet's syndrome (3.8%), pregnancy (6%), oral contraceptives (3.8%) and other drugs (3.8%). The aetiology of EN was not found in 35% of the patients. Sarcoidosis and infections were frequent causes of EN, whereas autoimmune rheumatic diseases rarely cause EN.
结节性红斑（EN）是一种由炎症性、触痛性结节性病变组成的皮肤反应，与多种疾病过程相关。我们研究的目的是调查EN不同病因的发生率。在1984年至1990年期间，对132例EN患者进行了一项前瞻性研究。对所有患者的评估始于病史和家族史，以全面的体格检查以及详细的实验室和免疫学检查结束。此外，在有指征的情况下进行了各种诊断程序。110例患者（83%）为女性。她们的平均年龄为41.0±14.0岁，范围为18至79岁。35%的患者未发现EN的病因。28%的患者被诊断为结节病，17.3%为感染，1.5%为结核病。其他病因包括阿达马蒂亚迪斯 - 贝赫切特综合征（3.8%）、妊娠（6%）、口服避孕药（3.8%）和其他药物（3.8%）。35%的患者未发现EN的病因。结节病和感染是EN的常见病因，而自身免疫性风湿病很少导致EN。
