Kassab G S, Schatz A, Imoto K, Fung Y C
Department of Bioengineering, University of California, San Diego, La Jolla, 92093-0412, USA.
Ann Biomed Eng. 2000 Apr;28(4):424-30. doi: 10.1114/1.280.
To document the remodeling of the asymmetric branching pattern of the coronary right ventricular branches (RVBs) in right ventricular hypertrophy (RVH), we computed an asymmetry ratio, S, for the diameters and lengths of all vessels, defined as the ratio of the daughter diameters and lengths, respectively. We have previously induced RVH in pigs by pulmonary stenosis for five weeks. At autopsy, silicone elastomer casts of the right coronary arteries were made and the morphometric data on the branching pattern and vascular geometry of the RVB were collected. Data on smaller vessels were obtained from histological specimens while data on larger vessels were obtained from vascular casts. The results show that the diameter asymmetry ratio was significantly decreased in RVH hearts. The asymmetry ratios of diameters and lengths were used to compute the asymmetry ratios for vascular resistance and flow of the various daughter vessels. It was found that the degree of asymmetry of the resistance and flow were decreased, which implies that the flow heterogeneity at a bifurcation is decreased in the RVH hearts.
为记录右心室肥厚（RVH）时冠状动脉右心室分支（RVBs）不对称分支模式的重塑情况，我们计算了所有血管直径和长度的不对称比S，分别定义为子血管直径和长度的比值。我们之前通过肺动脉狭窄诱导猪发生RVH达五周时间。尸检时，制作了右冠状动脉的硅橡胶铸型，并收集了RVB分支模式和血管几何形状的形态学数据。较小血管的数据来自组织学标本，而较大血管的数据来自血管铸型。结果显示，RVH心脏的直径不对称比显著降低。直径和长度的不对称比用于计算各分支血管的阻力和血流不对称比。结果发现，阻力和血流的不对称程度降低，这意味着RVH心脏中分叉处的血流异质性降低。
