Paul W L, Munson E S, Maniscalco J E
Anesth Analg. 1976 Nov-Dec;55(6):849-52. doi: 10.1213/00000539-197611000-00022.
Cerebrospinal fluid (CSF) pressure was studied in 8 patients and 5 dogs during pneumoencephalography (PEG) or ventriculography in which either O2 or N2O was used as the contrast gas prior to and during N2O inhalation. In 7 patients, the use of O2 as the contrast gas increased CSF pressure 8.7 torr (range 4 to 12 torr) following N2O inhalation. In 1 patient, when N2O was used as the contrast gas, CSF pressure did not change after N2O inhalation. These findings were confirmed in anesthetized animals ventilated at a constant PaCO2. The authors conclude that if N2O inhalation is required during PEG, maximum patient safety can be achieved if the contrast gas is also N2O.
在8例患者和5只犬进行气脑造影（PEG）或脑室造影期间研究了脑脊液（CSF）压力，在吸入氧化亚氮（N2O）之前和期间，使用氧气（O2）或N2O作为造影气体。在7例患者中，使用O2作为造影气体，吸入N2O后CSF压力升高8.7托（范围为4至12托）。在1例患者中，当使用N2O作为造影气体时，吸入N2O后CSF压力未改变。在以恒定动脉血二氧化碳分压（PaCO2）通气的麻醉动物中证实了这些发现。作者得出结论，如果在PEG期间需要吸入N2O，若造影气体也为N2O，则可实现最大程度的患者安全。
