Rovaris M, Filippi M
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, via Olgettina 60, 20132 Milan, Italy.
J Neurovirol. 2000 May;6 Suppl 2:S172-5.
Studies with conventional magnetic resonance imaging (MRI) support the hypothesis that cognitive impairment in multiple sclerosis (MS) patients is related with the lesion burden. Patterns of frontal lobe cognitive decline were also found to be related with the corresponding regional lesion load, although the total lesion load on T2-weighted MRI scans of the brain seems to be more relevant in determining frontal lobe deficits. Other non-conventional MRI techniques with a higher specificity to the heterogeneous substrates of MS pathology, such as the assessment of hypointense lesion load on T1-weighted scans and the histogram analysis of magnetisation transfer ratio (MTR) maps, have recently been applied to MS cognitive studies. Results from these studies suggest that three factors play a role in the pathogenesis of MS dementia: the burden of MS lesions, the severity of the pathological damage within individual lesions and that of the normal-appearing white matter.
传统磁共振成像（MRI）研究支持这样一种假说，即多发性硬化症（MS）患者的认知障碍与病灶负担有关。尽管大脑T2加权MRI扫描上的总病灶负担在确定额叶缺陷方面似乎更具相关性，但也发现额叶认知衰退模式与相应区域的病灶负荷有关。其他对MS病理异质底物具有更高特异性的非传统MRI技术，如T1加权扫描上低信号病灶负荷的评估和磁化传递率（MTR）图的直方图分析，最近已应用于MS认知研究。这些研究结果表明，三个因素在MS痴呆的发病机制中起作用：MS病灶负担、单个病灶内病理损伤的严重程度以及外观正常的白质的严重程度。
