Clausen P, Jensen J S, Borch-Johnsen K, Jensen G, Feldt-Rasmussen B
Medical Department P, State University Hospital, Copenhagen, Denmark.
Scand Cardiovasc J. 2000;34(2):159-63. doi: 10.1080/14017430050142170.
An elevated urinary albumin excretion (UAE) in non-diabetic subjects without renal or cardiovascular disease has been shown to be predictive of ischaemic heart disease. An insertion (I)/deletion (D) polymorphism in the angiotensin I-converting enzyme (ACE) gene has been identified and the D allele may be associated with cardiovascular disease. The aim of this study was to find a potential linkage between this polymorphism and elevated UAE. For studies of UAE and cardiovascular pathophysiology, a highly selected population sample has been identified comprising all clinically healthy subjects aged 40-65 years with elevated UAE in a dipstick negative urinary sample (n = 27) from The Copenhagen City Heart Study. Neither the ACE genotype distribution (p = 0.12) nor the D and I allele frequencies (p = 0.69) differed significantly between subjects with elevated UAE and a matched normoalbuminuric control group (n = 46). Elevated UAE in clinically healthy subjects is not linked to the ACE gene polymorphism.
在无肾脏或心血管疾病的非糖尿病受试者中，尿白蛋白排泄量（UAE）升高已被证明可预测缺血性心脏病。血管紧张素I转换酶（ACE）基因中的插入（I）/缺失（D）多态性已被识别，D等位基因可能与心血管疾病有关。本研究的目的是找出这种多态性与UAE升高之间的潜在联系。为了研究UAE和心血管病理生理学，我们从哥本哈根市心脏研究中选取了一个经过高度筛选的人群样本，包括所有年龄在40 - 65岁、尿试纸检测为阴性但UAE升高的临床健康受试者（n = 27）。UAE升高的受试者与匹配的正常白蛋白尿对照组（n = 46）之间，ACE基因型分布（p = 0.12）以及D和I等位基因频率（p = 0.69）均无显著差异。临床健康受试者中UAE升高与ACE基因多态性无关。
