Spencer J P, Chaudry F, Pannala A S, Srai S K, Debnam E, Rice-Evans C
Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College, London, United Kingdom.
Biochem Biophys Res Commun. 2000 May 27;272(1):236-41. doi: 10.1006/bbrc.2000.2749.
There is considerable interest in the bioavailability of flavonoids and phenolic components of the diet and their bioactivity in vivo. However, little is known of pre-absorption events in the gastric lumen. The effects of the acidic environment, as found in the gastric milieu, on procyanidin oligomers of catechin polyphenols has been investigated. The results show that under these conditions the procyanidin oligomers (trimer to hexamer) are hydrolysed to mixtures of epicatechin monomer and dimer, thus enhancing the potential for their absorption in the small intestine.
人们对饮食中黄酮类化合物和酚类成分的生物利用度及其体内生物活性非常感兴趣。然而，对于胃腔内吸收前的事件却知之甚少。已研究了胃环境中酸性环境对儿茶素多酚原花青素低聚物的影响。结果表明，在这些条件下，原花青素低聚物（三聚体至六聚体）被水解为表儿茶素单体和二聚体的混合物，从而增加了它们在小肠中被吸收的可能性。
