Berry R J, Mole R H, Barnes D W
Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Dec;30(6):535-41. doi: 10.1080/09553007614551391.
Skin reaction to X-irradiation has been studied in the albino guinea-pig; early response in limited-field irradiations of the flank is comparable to that commonly seen in rodents, swine and man, and is dose-dependent with a dynamic range from mild erythema to moist desquamation. The peak early skin reaction is seen between 14 and 21 days after irradiation, and declines before 30 days except at the highest doses used. Fractionation of the X-ray dose at 24 hours results in a 'sparing' of about 340 rad. Permanent partial epilation is detectable at doses in excess of 1400 rad, and complete epilation at 1 year occurs in 50 per cent of irradiated fields at 1740 rad. Twenty-four hour two-dose fractionation results in a 'sparing' of about 500 rad for epilation. Palpable dermal 'fibrosis' is detectable at 3 months after irradiation in fields given more than 2070 rad, and at 1 year after irradiation in fields given more than 1800 rad; 50 per cent of fields showed palpable 'fibrosis' at 1 year at 1930 rad. Unlike domestic swine and man, skin fields in the guinea-pig showed no dimensional contraction after X-ray doses which produced gross early skin damage.
对白化豚鼠的X射线皮肤反应进行了研究；腹部有限区域照射的早期反应与啮齿动物、猪和人类常见的反应相当，且呈剂量依赖性，动态范围从轻度红斑到湿性脱屑。早期皮肤反应峰值出现在照射后14至21天之间，除了使用的最高剂量外，在30天前反应会下降。在24小时对X射线剂量进行分次照射会产生约340拉德的“剂量节省”。超过1400拉德的剂量可检测到永久性部分脱毛，在1740拉德时，1年时有50%的照射区域出现完全脱毛。24小时两剂量分次照射会产生约500拉德的脱毛“剂量节省”。在接受超过2070拉德照射的区域，照射后3个月可检测到明显的皮肤“纤维化”，在接受超过1800拉德照射的区域，照射后1年可检测到明显的皮肤“纤维化”；在1930拉德时，1年时有50%的区域出现明显的“纤维化”。与家猪和人类不同，豚鼠的皮肤区域在产生明显早期皮肤损伤的X射线剂量后未出现尺寸收缩。
