Ganly I, Soutar D S, Kaye S B
Department of Head and Neck Plastic and Reconstructive Surgery, Canniesburn Hospital, Switchback Road, Bearsden, Glasgow, G61 1BD, Scotland.
Eur J Surg Oncol. 2000 Jun;26(4):338-43. doi: 10.1053/ejso.1999.0895.
Our increasing knowledge of cancer molecular biology has led to the development of new genetic therapies for the treatment of cancer. Such therapies are advantageous in that they can selectively target tumour tissue leaving normal tissue relatively unaffected. In squamous cell cancer of the head and neck, such therapies may be beneficial in the treatment of loco-regional recurrence, minimal residual disease and in the treatment of distant metastatic disease. This article describes the principles of cancer gene therapy reviews some early clinical trials of gene therapy in head and neck cancer.
我们对癌症分子生物学的了解日益深入，这促使了用于治疗癌症的新基因疗法的发展。此类疗法的优势在于它们能够选择性地靶向肿瘤组织，而使正常组织相对不受影响。在头颈部鳞状细胞癌中，此类疗法在治疗局部区域复发、微小残留病灶以及远处转移性疾病方面可能具有益处。本文阐述了癌症基因治疗的原理，并回顾了一些头颈部癌症基因治疗的早期临床试验。
