Bremers A J, Kuppen P J, Parmiani G
Unit of Human Tumour Immunotherapy, Istituto Nazionale dei Tumori, Milan, Italy.
Eur J Surg Oncol. 2000 Jun;26(4):418-24. doi: 10.1053/ejso.1999.0908.
In the course of a century, tumour immunology has revealed a picture of a very complex immune system involving the recognition and eradication of malignancies. Many tumours evade the immune system, and understanding of tumour escape mechanisms is the key to a successful immunotherapy for cancer. A wide array of tumour immunotherapy modalities have been developed, many of which have reached the phase of clinical trials, with some satisfactory results. Based on the available clinical, data and the techniques available for further improvement, we analyse the prospects for the different treatment modalities, and predict an important role for tumour immunotherapy in the near future.
在一个世纪的进程中，肿瘤免疫学揭示了一个涉及识别和根除恶性肿瘤的极其复杂的免疫系统。许多肿瘤能逃避免疫系统，而了解肿瘤逃逸机制是癌症免疫治疗成功的关键。已经开发出了一系列肿瘤免疫治疗方法，其中许多已进入临床试验阶段，并取得了一些令人满意的结果。基于现有的临床数据和可用于进一步改进的技术，我们分析了不同治疗方法的前景，并预测肿瘤免疫治疗在不久的将来将发挥重要作用。
