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The role of CD4 and CD8 T cells in recovery and protection from retroviral infection: lessons from the Friend virus model.

作者信息

Hasenkrug K J, Dittmer U

机构信息

Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, Montana, 59840, USA.

出版信息

Virology. 2000 Jul 5;272(2):244-9. doi: 10.1006/viro.2000.0387.

DOI:10.1006/viro.2000.0387
PMID:10873767
Abstract
摘要

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The role of CD4 and CD8 T cells in recovery and protection from retroviral infection: lessons from the Friend virus model.CD4和CD8 T细胞在从逆转录病毒感染中恢复及获得保护方面的作用:来自弗瑞德病毒模型的经验教训
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Kinetics of CD8+ effector T cell responses and induced CD4+ regulatory T cell responses during Friend retrovirus infection.弗氏逆转录病毒感染期间CD8 +效应T细胞反应和诱导性CD4 +调节性T细胞反应的动力学
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Identification of a protective CD4+ T-cell epitope in p15gag of Friend murine leukemia virus and role of the MA protein targeting the plasma membrane in immunogenicity.鉴定弗氏小鼠白血病病毒p15gag中一种保护性CD4 + T细胞表位以及靶向质膜的基质蛋白在免疫原性中的作用。
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Different immunological requirements for protection against acute versus persistent Friend retrovirus infections.针对急性与持续性弗氏逆转录病毒感染的防护,存在不同的免疫需求。
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Role of natural killer cells in resistance against friend retrovirus-induced leukemia.自然杀伤细胞在抗Friend逆转录病毒诱导的白血病中的作用。
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Anti-retroviral effects of type I IFN subtypes in vivo.I型干扰素亚型在体内的抗逆转录病毒作用。
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Immune control and prevention of chronic Friend retrovirus infection.慢性Friend逆转录病毒感染的免疫控制与预防
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Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection.病毒中和抗体在针对弗氏逆转录病毒感染的无菌免疫中起关键作用。
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Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia.主要组织相容性复合体I类基因控制着对从Friend逆转录病毒诱导的白血病中恢复很重要的产生γ干扰素的CD4(+)和CD8(+) T细胞的生成。
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