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转录调控：印记绝缘

Transcriptional control: imprinting insulation.

作者信息

Wolffe A P

机构信息

Sangamo Biosciences Inc, Point Richmond Tech Center, Richmond, CA 94804,USA.

出版信息

Curr Biol. 2000 Jun 15;10(12):R463-5. doi: 10.1016/s0960-9822(00)00534-0.

DOI:10.1016/s0960-9822(00)00534-0
PMID:10873799
Abstract

Recent studies on the transcriptional regulation of two linked, imprinted genes, Igf2 and H19, have provided evidence for a novel mechanism of epigenetic control. DNA methylation controls the activity of an insulator element located between the two linked genes by regulating the binding of the zinc-finger protein CTCF.

摘要

最近对两个连锁的印记基因Igf2和H19转录调控的研究，为一种新的表观遗传控制机制提供了证据。DNA甲基化通过调节锌指蛋白CTCF的结合来控制位于这两个连锁基因之间的一个绝缘子元件的活性。

相似文献

1
Transcriptional control: imprinting insulation.转录调控：印记绝缘
Curr Biol. 2000 Jun 15;10(12):R463-5. doi: 10.1016/s0960-9822(00)00534-0.
2
The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains.负责染色质绝缘子蛋白CTCF与H19印记控制区域之间直接物理接触的核苷酸表现出亲本来源特异性的长距离绝缘和无甲基化结构域。
Genes Dev. 2003 Mar 1;17(5):586-90. doi: 10.1101/gad.254903.
3
Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive.CTCF与H19基因上游绝缘子的功能关联具有亲本来源特异性且对甲基化敏感。
Curr Biol. 2000 Jul 13;10(14):853-6. doi: 10.1016/s0960-9822(00)00597-2.
4
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene.一种依赖CTCF的边界的甲基化控制Igf2基因的印记表达。
Nature. 2000 May 25;405(6785):482-5. doi: 10.1038/35013100.
5
Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site.骨肉瘤中IGF2和H19印记缺失伴随着CTCF结合位点的相互甲基化变化。
Hum Mol Genet. 2003 Mar 1;12(5):535-49. doi: 10.1093/hmg/ddg034.
6
A loss of insulin-like growth factor-2 imprinting is modulated by CCCTC-binding factor down-regulation at senescence in human epithelial cells.胰岛素样生长因子-2印记缺失在人上皮细胞衰老过程中通过CCCTC结合因子下调受到调控。
J Biol Chem. 2004 Dec 10;279(50):52218-26. doi: 10.1074/jbc.M405015200. Epub 2004 Oct 7.
7
An evolutionarily conserved putative insulator element near the 3' boundary of the imprinted Igf2/H19 domain.印记基因Igf2/H19结构域3'边界附近一个进化保守的假定绝缘子元件。
Hum Mol Genet. 2002 Jul 1;11(14):1627-36. doi: 10.1093/hmg/11.14.1627.
8
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus.CCCTC结合因子（CTCF）介导H19/胰岛素样生长因子2（Igf2）基因座处的甲基化敏感增强子阻断活性。
Nature. 2000 May 25;405(6785):486-9. doi: 10.1038/35013106.
9
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance.H19印记控制区内单个CTCF靶位点的突变会导致Igf2印记丢失以及母系遗传时出现复杂的从头甲基化模式。
Mol Cell Biol. 2004 Apr;24(8):3497-504. doi: 10.1128/MCB.24.8.3497-3504.2004.
10
Nonallelic transcriptional roles of CTCF and cohesins at imprinted loci.非等位基因转录因子 CTCF 和黏合蛋白在印迹基因座上的作用。
Mol Cell Biol. 2011 Aug;31(15):3094-104. doi: 10.1128/MCB.01449-10. Epub 2011 May 31.

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Increased Intragenic IGF2 Methylation is Associated with Repression of Insulator Activity and Elevated Expression in Serous Ovarian Carcinoma.基因内 IGF2 甲基化增加与绝缘子活性抑制和浆液性卵巢癌表达升高有关。
Front Oncol. 2013 May 24;3:131. doi: 10.3389/fonc.2013.00131. eCollection 2013.
6
Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II.CCCTC 结合因子诱饵蛋白中断染色体内环化可消除人胰岛素样生长因子 II 的基因组印记。
J Cell Biol. 2011 May 2;193(3):475-87. doi: 10.1083/jcb.201101021.
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CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop.CTCF通过协调启动子-多梳抑制复合物2的染色体内环来调控Igf2的等位基因表达。
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8
Identification of clustered YY1 binding sites in imprinting control regions.印记控制区域中YY1结合位点簇的鉴定。
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9
Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice.Tsix中Xite和CTCF位点的差异甲基化反映了小鼠X染色体失活选择的模式。
Mol Cell Biol. 2006 Mar;26(6):2109-17. doi: 10.1128/MCB.26.6.2109-2117.2006.
10
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