文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Machelska H, Stein C

Klinik für Anaesthesiologie und operative Intensivmedizin, Klinikum Benjamin Franklin, Freie Universität Berlin, Germany.

Clin Exp Pharmacol Physiol. 2000 Jul;27(7):533-6. doi: 10.1046/j.1440-1681.2000.03287.x.

The nervous and immune systems communicate with each other by use of cytokines and neuropeptides. 2. Interactions between immune cell-derived opioid peptides and opioid receptors located in peripheral inflamed tissue lead to endogenous analgesia. 3. In addition to their immunological functions, immunocytes are involved in intrinsic pain inhibition. This provides new insights into pain associated with a compromised immune system, as in AIDS or in cancer. 4. The activation of opioid production and release from immune cells may be a novel approach to the development of peripherally acting analgesics. Because such drugs would be targeted towards events in peripheral injured tissue, these analgesics should lack unwanted central side effects typically associated with opioids.

神经系统和免疫系统通过细胞因子和神经肽相互通信。2. 免疫细胞衍生的阿片肽与位于外周炎症组织中的阿片受体之间的相互作用导致内源性镇痛。3. 免疫细胞除了具有免疫功能外，还参与内在的疼痛抑制。这为与免疫系统受损相关的疼痛提供了新的见解，如在艾滋病或癌症中。4. 激活免疫细胞产生和释放阿片类物质可能是开发外周作用镇痛药的一种新方法。由于这类药物将针对外周损伤组织中的事件，这些镇痛药应缺乏通常与阿片类药物相关的不良中枢副作用。

Machelska H, Stein C

Klinik für Anaesthesiologie und operative Intensivmedizin, Klinikum Benjamin Franklin, Freie Universität Berlin, Germany.

Clin Exp Pharmacol Physiol. 2000 Jul;27(7):533-6. doi: 10.1046/j.1440-1681.2000.03287.x.

The nervous and immune systems communicate with each other by use of cytokines and neuropeptides. 2. Interactions between immune cell-derived opioid peptides and opioid receptors located in peripheral inflamed tissue lead to endogenous analgesia. 3. In addition to their immunological functions, immunocytes are involved in intrinsic pain inhibition. This provides new insights into pain associated with a compromised immune system, as in AIDS or in cancer. 4. The activation of opioid production and release from immune cells may be a novel approach to the development of peripherally acting analgesics. Because such drugs would be targeted towards events in peripheral injured tissue, these analgesics should lack unwanted central side effects typically associated with opioids.

神经系统和免疫系统通过细胞因子和神经肽相互通信。2. 免疫细胞衍生的阿片肽与位于外周炎症组织中的阿片受体之间的相互作用导致内源性镇痛。3. 免疫细胞除了具有免疫功能外，还参与内在的疼痛抑制。这为与免疫系统受损相关的疼痛提供了新的见解，如在艾滋病或癌症中。4. 激活免疫细胞产生和释放阿片类物质可能是开发外周作用镇痛药的一种新方法。由于这类药物将针对外周损伤组织中的事件，这些镇痛药应缺乏通常与阿片类药物相关的不良中枢副作用。