Spitzweg C, Morris J C
Mayo Medical School, Rochester, Minnesota, USA.
Endocrinol Metab Clin North Am. 2000 Jun;29(2):389-98, viii. doi: 10.1016/s0889-8529(05)70138-9.
In addition to physiologic, diagnostic, and therapeutic implications, the recently cloned and characterized sodium iodide symporter (NIS) also may play an important role in the pathogenesis of autoimmune thyroid disease. Sodium iodide symporter expression patterns characteristically are changed in autoimmune thyroid disease, including Graves' disease and Hashimoto's thyroiditis, which may be caused, in part, by the regulation of sodium iodide symporter expression of cytokines involved in the pathogenesis of autoimmune thyroid disease. Further, there is increasing evidence that NIS-directed antibodies are present in sera from patients with autoimmune thyroid disease, and these antibodies also may affect NIS functional activity.
除了具有生理、诊断和治疗意义外，最近克隆并鉴定的钠碘同向转运体（NIS）在自身免疫性甲状腺疾病的发病机制中也可能起重要作用。在自身免疫性甲状腺疾病（包括格雷夫斯病和桥本甲状腺炎）中，钠碘同向转运体的表达模式有特征性改变，这可能部分是由参与自身免疫性甲状腺疾病发病机制的细胞因子对钠碘同向转运体表达的调节所致。此外，越来越多的证据表明，自身免疫性甲状腺疾病患者的血清中存在针对NIS的抗体，这些抗体也可能影响NIS的功能活性。
