McKelvey W, Greenland S, Sandler R S
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, USA.
Epidemiology. 2000 Jul;11(4):469-73. doi: 10.1097/00001648-200007000-00018.
The trans fatty acids in partially hydrogenated vegetable oil may cause colorectal neoplasia by interfering with cell membrane function or eicosanoid metabolism. This possibility provided a rationale for looking at the relation between colorectal adenomas and consumption of foods containing partially hydrogenated vegetable oils in 234 cases and 407 controls recruited from referrals for colonoscopy at University of North Carolina Hospitals in Chapel Hill, between 1988 and 1990. Foods containing partially hydrogenated vegetable oils were divided into four groups: sweetened baked goods, chocolate candy, oils and condiments, and french fries and chips. We observed no evidence of increased adenoma prevalence associated with consumption of fries and chips (200+ vs 0 kcals/day: odds ratio (OR) = 0.70; 95% confidence limits (CL) = 0.27, 1.8) or chocolate candy (50+ vs 0 kcals/day: OR = 0.49; 95% CL = 0.23, 1.1). We did, however, find evidence of increased adenoma prevalence associated with consumption of sweetened baked goods (400+ vs < 100 kcals/day: OR = 1.9; 95% CL = 0.95, 3.8) and oils and condiments (200+ vs < 100 kcals/day: OR = 2.4; 95% CL = 1.3, 4.2).
部分氢化植物油中的反式脂肪酸可能通过干扰细胞膜功能或类花生酸代谢而导致结直肠肿瘤。这种可能性为研究1988年至1990年间在北卡罗来纳大学教堂山分校医院因结肠镜检查转诊而来的234例病例和407例对照中结直肠腺瘤与含部分氢化植物油食品的消费之间的关系提供了理论依据。含部分氢化植物油的食品分为四类：甜味烘焙食品、巧克力糖果、油和调味品以及炸薯条和薯片。我们没有观察到与食用炸薯条和薯片（每天200千卡以上与0千卡：优势比（OR）=0.70；95%置信区间（CL）=0.27，1.8）或巧克力糖果（每天50千卡以上与0千卡：OR =0.49；95%CL =0.23，1.1）相关的腺瘤患病率增加的证据。然而，我们确实发现了与食用甜味烘焙食品（每天400千卡以上与<100千卡：OR =1.9；95%CL =0.95，3.8）和油及调味品（每天200千卡以上与<100千卡：OR =2.4；95%CL =1.3，4.2）相关的腺瘤患病率增加的证据。
