Schliephake H, Dard M, Planck H, Hierlemann H, Stern U
Department of Oral and Maxillofacial Surgery, Hannover Medical School, Germany.
Int J Oral Maxillofac Implants. 2000 May-Jun;15(3):364-73.
The aim of this experimental study was to evaluate the use of autogenous bone harvested during preparation of implant sites in combination with resorbable membranes for vertical ridge augmentation under 2 different defect site conditions. Combined vertical/horizontal alveolar bone defects were created by experimentally induced periodontal infections around all premolar teeth in the mandibles of 3 dogs (group 1). In another 3 dogs, fresh surgical defects were created after extraction of all premolar teeth in the mandibles (group 2). In all dogs, 2 implants were placed on each side of the mandible into the defect areas. One implant on each side of the mandible received augmentation with autogenous bone particles, and both implants on one side of the mandible were covered with polylactic acid membranes. After 5 months, the material was evaluated histologically. There was a small but significant increase in bone regeneration in the defects augmented with bone particles with and without membrane coverage in group 1. In group 2, no significant difference was seen between the controls and the augmented sites. The major limiting effect for bone regeneration appeared to be insufficient stability of the bone material to withstand the overlying soft tissue pressure. It was concluded that the placement of autogenous bone particles, either with or without membrane coverage, had little effect on the regeneration of peri-implant bone defects.
本实验研究的目的是评估在两种不同缺损部位情况下，将种植位点制备过程中采集的自体骨与可吸收膜联合用于垂直牙槽嵴增高的效果。通过实验诱导3只犬下颌所有前磨牙周围发生牙周感染，制造垂直/水平联合牙槽骨缺损（第1组）。在另外3只犬中，拔除下颌所有前磨牙后制造新鲜手术缺损（第2组）。在所有犬中，在下颌每侧的缺损区域植入2枚种植体。下颌每侧的1枚种植体用自体骨颗粒进行增高，下颌一侧的2枚种植体均用聚乳酸膜覆盖。5个月后，对材料进行组织学评估。在第1组中，有膜覆盖和无膜覆盖的骨颗粒增高的缺损部位，骨再生均有小幅但显著的增加。在第2组中，对照部位和增高部位之间未见显著差异。骨再生的主要限制作用似乎是骨材料稳定性不足，无法承受上方软组织的压力。得出的结论是，无论有无膜覆盖，自体骨颗粒的植入对种植体周围骨缺损的再生影响不大。
