Turhan N O, Karabulut A, Adam B
Department of Obstetrics and Gynecology, Fatih University Medical School, Ankara, Turkey.
J Perinat Med. 2000;28(2):133-9. doi: 10.1515/JPM.2000.018.
To evaluate the diagnostic value of maternal serum interleukin 6 (IL-6), C-reactive protein (CRP) levels and white blood cell (WBC) count for the prediction of preterm labor and length of admission-to-delivery interval in patients with preterm labor.
Maternal serum IL-6, CRP and WBC count were prospectively determined in eighty-two patients in preterm labor and 21 controls. Data was analyzed in study and control groups, and for the assessment of clinical and laboratory risk factors in the prediction of admission-to-delivery interval in the study group.
Maternal serum IL-6 levels were significantly higher in the study group than controls. The IL-6 value associated with the highest percent of true positives and true negatives for the prediction of preterm labor was 5 pg/ml. The area under curve of maternal IL-6 was significantly higher than the area under curve of of CRP and WBC count. In the study group maternal serum IL-6 levels were significantly higher in patients delivered within 2 and 7 days than the nondelivering ones and a cut off value of 8.3 pg/ml was determined for estimation of preterm delivery.
Maternal serum IL-6 is a reliable marker in the prediction and management of preterm labor and delivery.
评估孕妇血清白细胞介素6（IL-6）、C反应蛋白（CRP）水平及白细胞（WBC）计数对早产预测及早产患者入院至分娩间隔时间的诊断价值。
前瞻性测定82例早产患者及21例对照者的孕妇血清IL-6、CRP及WBC计数。对研究组和对照组的数据进行分析，并评估研究组中预测入院至分娩间隔时间的临床和实验室危险因素。
研究组孕妇血清IL-6水平显著高于对照组。预测早产时真阳性和真阴性百分比最高的IL-6值为5 pg/ml。孕妇IL-6的曲线下面积显著高于CRP和WBC计数的曲线下面积。在研究组中，2天内和7天内分娩的患者孕妇血清IL-6水平显著高于未分娩者，并确定了8.3 pg/ml的截断值用于估计早产。
孕妇血清IL-6是早产预测和管理的可靠标志物。
