Sasamata M, Moskowitz M A, Lo E H
Pharmacology Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nihon Yakurigaku Zasshi. 2000 Mar;115(3):161-9. doi: 10.1254/fpj.115.161.
Recently, we established a novel temporal correlation mapping (TCM) technique in combination with high-resolution functional computed tomography (CT) scanning to analyze the temporal changes in bolus transit dynamics of iodinated contrast agents in focal cerebral ischemia. Based on changes in the temporal dynamics of blood flow, we defined a new kind of penumbra and core in focal ischemia: the hemodynamic penumbra and hemodynamic core. We visualized for the first time a larger hemodynamic core and smaller hemodynamic penumbra in endothelial NOS knockout mice than in wild type mice early after focal ischemia by using the TCM analysis technique. In addition, neuroprotective effects of the water-soluble AMPA receptor antagonist YM872 were for the first time observed in the hemodynamic penumbra after focal ischemia. In conclusion, early TCM analysis could be used to directly and quantitatively evaluate the effects of neuroprotective therapy and the evolution of neuronal damage in the hemodynamic penumbra.
最近，我们结合高分辨率功能计算机断层扫描（CT）建立了一种新型的时间相关性映射（TCM）技术，以分析局灶性脑缺血中碘化造影剂团注传输动力学的时间变化。基于血流时间动态变化，我们在局灶性缺血中定义了一种新型的半暗带和核心：血流动力学半暗带和血流动力学核心。通过使用TCM分析技术，我们首次发现在局灶性缺血早期，内皮型一氧化氮合酶基因敲除小鼠中的血流动力学核心比野生型小鼠更大，血流动力学半暗带更小。此外，首次观察到水溶性AMPA受体拮抗剂YM872对局灶性缺血后血流动力学半暗带具有神经保护作用。总之，早期TCM分析可用于直接和定量评估神经保护治疗的效果以及血流动力学半暗带中神经元损伤的演变。
