早老素缺陷胚胎干细胞中γ-分泌酶活性的完全失活。 - Suppr

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

作者信息

Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B

机构信息

Neuronal Cell Biology Laboratory, CME, K.U.Leuven and Flanders Interuniversitary Institute for Biotechnology (VIB4), Belgium.

出版信息

Nat Cell Biol. 2000 Jul;2(7):461-2. doi: 10.1038/35017105.

DOI:10.1038/35017105

PMID:10878813

Abstract

摘要

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引用本文的文献

TCR activation stimulates regulated intramembrane proteolysis of L-selectin by presenilin 1 and localized proteasomal degradation of the cytoplasmic tail.

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Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion.

J Extracell Vesicles. 2025 Jan;14(1):e70019. doi: 10.1002/jev2.70019.

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Life Sci Alliance. 2024 Dec 11;8(3). doi: 10.26508/lsa.202403122. Print 2025 Mar.

The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease.

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J Biol Chem. 2023 Jun;299(6):104794. doi: 10.1016/j.jbc.2023.104794. Epub 2023 May 9.

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

作者信息

Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B

机构信息

Neuronal Cell Biology Laboratory, CME, K.U.Leuven and Flanders Interuniversitary Institute for Biotechnology (VIB4), Belgium.

出版信息

Nat Cell Biol. 2000 Jul;2(7):461-2. doi: 10.1038/35017105.

DOI:10.1038/35017105

PMID:10878813

Abstract

摘要

相似文献

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

Nat Cell Biol. 2000 Jul;2(7):461-2. doi: 10.1038/35017105.

Alzheimer's disease. Closing in on gamma-secretase.

Nature. 2000 Jun 8;405(6787):627, 629. doi: 10.1038/35015193.

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.

Nat Cell Biol. 2000 Jul;2(7):463-5. doi: 10.1038/35017108.

Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.

J Neurochem. 2004 Aug;90(4):800-6. doi: 10.1111/j.1471-4159.2004.02512.x.

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.

J Neurochem. 2006 Feb;96(3):732-42. doi: 10.1111/j.1471-4159.2005.03578.x. Epub 2006 Jan 9.

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.

J Neurochem. 2005 Sep;94(5):1189-201. doi: 10.1111/j.1471-4159.2005.03266.x. Epub 2005 Jun 30.

[Alzheimer's disease: focus on beta-amyloid and gamma-secretase].

Tanpakushitsu Kakusan Koso. 2004 May;49(7 Suppl):1086-90.

Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.

J Neurosci Res. 2003 Nov 1;74(3):386-92. doi: 10.1002/jnr.10745.

Presenilin-1 mutations in Alzheimer's disease.

Nature. 2000 Jun 1;405(6786):531-2. doi: 10.1038/35014735.

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11039-41. doi: 10.1073/pnas.211352598.

引用本文的文献

TCR activation stimulates regulated intramembrane proteolysis of L-selectin by presenilin 1 and localized proteasomal degradation of the cytoplasmic tail.

J Biol Chem. 2025 Jul 10;301(8):110473. doi: 10.1016/j.jbc.2025.110473.

γ-secretase targeting in Alzheimer's disease.

J Alzheimers Dis Rep. 2025 Jun 23;9:25424823251349529. doi: 10.1177/25424823251349529. eCollection 2025 Jan-Dec.

Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion.

J Extracell Vesicles. 2025 Jan;14(1):e70019. doi: 10.1002/jev2.70019.

Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells.

Life Sci Alliance. 2024 Dec 11;8(3). doi: 10.26508/lsa.202403122. Print 2025 Mar.

The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease.

Cell Death Dis. 2024 May 28;15(5):367. doi: 10.1038/s41419-024-06742-2.

Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform.

Nat Commun. 2024 May 27;15(1):4479. doi: 10.1038/s41467-024-48776-2.

Selective inhibitors of the PSEN1-gamma-secretase complex.

J Biol Chem. 2023 Jun;299(6):104794. doi: 10.1016/j.jbc.2023.104794. Epub 2023 May 9.

Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP.

EMBO J. 2022 Nov 2;41(21):e111084. doi: 10.15252/embj.2022111084. Epub 2022 Sep 19.

Parkin as a Molecular Bridge Linking Alzheimer's and Parkinson's Diseases?

Biomolecules. 2022 Apr 9;12(4):559. doi: 10.3390/biom12040559.

γ-Secretase in Alzheimer's disease.

Exp Mol Med. 2022 Apr;54(4):433-446. doi: 10.1038/s12276-022-00754-8. Epub 2022 Apr 8.

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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