[三磷酸腺苷对离体心脏对肾上腺素敏感性的影响]
[Effect of ATP on the sensitivity of the from heart to adrenaline].
作者信息
Putintseva T G
出版信息
Fiziol Zh SSSR Im I M Sechenova. 1976 Oct;62(10):1495-9.
PMID:1087909
Abstract
Adenosinthreephosphoric acid (ATP) in concentration 1-10(-6)--1-10(-5) g/ml decreases sensitivity of the frog heart muscle to adrenaline by half. It is suggested that ATP present in the specific granules of adrenals, c. n. s. and adrenergic axons together with catecholamines and excreted with the mediator during excitation of adrenergic nerve, alters the sensitivity of postsynaptic membrane to adrenaline.
摘要
浓度为1×10⁻⁶ - 1×10⁻⁵克/毫升的三磷酸腺苷（ATP）可使蛙心肌对肾上腺素的敏感性降低一半。有人提出，存在于肾上腺、中枢神经系统和肾上腺素能轴突的特定颗粒中的ATP，与儿茶酚胺一起，在肾上腺素能神经兴奋时随介质排出，会改变突触后膜对肾上腺素的敏感性。
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