Macey M G, Jawad N, McCarthy D A, Newland A C, Brown K A
Department of Hematology, The Royal London Hospital, UK.
Immunobiology. 2000 May;202(1):59-67. doi: 10.1016/S0171-2985(00)80053-4.
Blood dendritic cell precursors (DCps) are identified as mononuclear leukocytes expressing HLA-DR but lacking the characteristic antigens associated with T cells (CD3), NK cells (CD16 and CD56) and B cells (CD 19). Dendritic cell precursors are distinguished from monocytes by their lack of expression of CD64 rather than of CD14. This study investigated whether CD14- DCps differed from CD64-DCps, which were predominantly CD14+, in their expression of five well-characterised adhesion molecules. There were significantly fewer cells expressing CD11b, CD18 and CD29 in the CD64-DCp population compared with CD14- DCps, and this CD64- DCp subpopulation also had a lower expression of CD11b and CD18. Our results suggest that the two DC precursor subpopulations may differ from one another in their binding characteristics to blood vessel walls and to other leukocytes.
血液树突状细胞前体（DCps）被鉴定为表达HLA - DR但缺乏与T细胞（CD3）、NK细胞（CD16和CD56）以及B细胞（CD19）相关特征性抗原的单核白细胞。树突状细胞前体与单核细胞的区别在于其不表达CD64而非CD14。本研究调查了CD14 - DCps与主要为CD14 + 的CD64 - DCps在五种特征明确的黏附分子表达上是否存在差异。与CD14 - DCps相比，CD64 - DCp群体中表达CD11b、CD18和CD29的细胞明显更少，并且这个CD64 - DCp亚群中CD11b和CD18的表达也较低。我们的结果表明，这两个DC前体亚群在与血管壁及其他白细胞的结合特性上可能彼此不同。
