Rebattu P, Coudert B, Schneider M, Ouabdesselam R, Lentz M, Hanauske A, Chevallierdagger B, Fumoleau P, Chollet P
Centre Léon Berard, 28 rue Laennec, 69373 Lyon Cedex 08, France.
Rev Pneumol Clin. 2000 Jun;56(3):200-3.
From January 1990 to November 1994, 23 patients with advanced pretreated lung carcinoma were enrolled into a phase II trial to test a new nitrosourea, cystemustine, given every 2 weeks at the dose of 60 mg/m(2) in a 15-minute IV infusion. All eligible patients were considered evaluable for response and toxicity (WHO criteria).
1990年1月至1994年11月,23例经前期治疗的晚期肺癌患者被纳入一项II期试验,以测试一种新的亚硝基脲——西司莫司汀,每2周静脉输注给药一次,剂量为60mg/m²,输注时间为15分钟。所有符合条件的患者均根据疗效和毒性(世界卫生组织标准)进行评估。