Epstein Y, Heled Y, Moran D, Shapiro Y
Institute of Military Medicine, Medical Corps, Israel Defense Forces.
Harefuah. 2000 May 1;138(9):713-8, 808.
The ability to predict the physiological responses of workers exposed to extreme environmental conditions, has been a challenge to environmental physiologists for more than 3 decades. Therefore, mathematical models have been developed to predict metabolic rate under various levels of work intensity and dynamic changes in body temperature and heart rate. Based on the effect of exercise on the cardiovascular system, a model was developed to predict mean arterial blood pressure as a function of heart rate. Physiological strain could also be estimated on the basis of thermoregulatory and cardiovascular strains. This paper summarizes knowledge accumulated during 25 years of studies in the field of mathematical modeling of physiological parameters. Besides analyzing the logic underlying each model, it explains the scientific approach in developing a model from its early concept to the model's application in the field.
30多年来，预测暴露在极端环境条件下的工人的生理反应的能力一直是环境生理学家面临的一项挑战。因此，已经开发出数学模型来预测在各种工作强度水平下的代谢率以及体温和心率的动态变化。基于运动对心血管系统的影响，开发了一个模型来预测作为心率函数的平均动脉血压。生理应变也可以根据体温调节和心血管应变来估计。本文总结了在生理参数数学建模领域25年研究中积累的知识。除了分析每个模型背后的逻辑，还解释了从模型的早期概念到其在该领域的应用的科学开发方法。
