Peretti G, Piazza C, Berlucchi M, Cavaliere S, Melloni G, Zannini P, Antonelli A R
Clinica Otorinolaringoiatrica dell'Università di Brescia.
Acta Otorhinolaryngol Ital. 2000 Feb;20(1):54-61.
Benign Pleomorphic Adenoma (PA) is a tumor rarely found in tracheal and laryngotracheal sites. A review of the literature published since 1922 has revealed only 30 certain cases of which 3 presented simultaneous involvement of both larynx and trachea. The present work describes the thirty-first case (the fourth with a laryngotracheal localization), diagnosed in a white, 40-year-old male who had been complaining of acute dyspnea for the last three years. Initially these symptoms had been interpreted as asthmatic crises. During one of these episodes, the patient underwent emergency tracheotomy and a laryngotracheoscopy revealed a rounded cricotracheal lesion with smooth surface and approximately 4 cm in cranio-caudal diameter. The mass occupied 90% of the air space and originated from the posterolateral right portion of the cricoid, and from the first 3 tracheal rings. CT and esophagoscopy ruled out its transmural invasion into the esophagus. Under rigid bronchoscopy, assisted NdYAG laser debulking was performed for biopsy purposes. The histological diagnosis was benign AP. For this reason a Grillo cricotracheal resection was performed with exeresis of the cricoid arch, mucosa of the cricoid plate and the first 4 tracheal rings. Reconstruction of the respiratory tract was achieved through termino-terminal cricothyrotracheal anastomosis. The initial diagnosis was confirmed and the resection edges were without evidence of neoplasm. Post-operative recovery proceeded without complications and the patient was discharged 7 days after surgery. Endoscopic and radiological follow-up after 30 months is still negative for any neoplastic recurrences. The laryngo-tracheal lumen is within the norm and cord motility has been preserved. The authors then describe the clinical, anatomopathological and radiological elements which prove useful in evaluating tracheal neoplasms and they underline the problems of differential diagnosis between benign AP and adenoid-cystic carcinoma. In addition, the various therapeutic options are discussed with special attention being focused on surgery through external approaches. Given the location of the AP described, the Grillo procedure-most commonly used in cases of inflammatory cricotracheal stenoses-proved well suited to the loco-regional control of the neoplasm. Stringent respect for some parts of this surgical technique make it possible to reduce post-operative complications to a minimum.
良性多形性腺瘤(PA)是一种罕见于气管和喉气管部位的肿瘤。对1922年以来发表的文献进行回顾发现,仅有30例确诊病例,其中3例同时累及喉和气管。本文描述了第31例病例(第4例喉气管定位病例),患者为一名40岁白人男性,过去三年一直抱怨急性呼吸困难。最初这些症状被解释为哮喘发作。在其中一次发作期间,患者接受了紧急气管切开术,喉镜检查发现环状气管有一个圆形病变,表面光滑,颅尾径约4厘米。肿块占据了90%的气道空间,起源于环状软骨后外侧右部及气管的前3个环。CT和食管镜检查排除了其向食管的透壁侵犯。在硬质支气管镜下,为活检目的进行了NdYAG激光减容术。组织学诊断为良性AP。因此,进行了Grillo环状气管切除术,切除环状软骨弓、环状软骨板黏膜及气管的前4个环。通过端端环状甲状腺气管吻合术实现呼吸道重建。初步诊断得到证实,切除边缘无肿瘤证据。术后恢复顺利,无并发症,患者术后7天出院。30个月后的内镜和放射学随访仍未发现任何肿瘤复发。喉气管腔正常,声带活动得以保留。作者随后描述了有助于评估气管肿瘤的临床、解剖病理学和放射学因素,并强调了良性AP与腺样囊性癌鉴别诊断的问题。此外,还讨论了各种治疗选择,特别关注通过外部途径进行的手术。鉴于所描述的AP的位置,Grillo手术(最常用于炎性环状气管狭窄病例)被证明非常适合肿瘤的局部区域控制。严格遵守该手术技术的某些部分可以将术后并发症降至最低。