钒酸盐低聚物对肌浆网钙泵被动和主动转运Ca2+的抑制作用。
Vanadate oligomer inhibition of passive and active Ca2+ translocation by the Ca2+ pump of sarcoplasmic reticulum.
作者信息
Aureliano M
机构信息
Chemistry-U.C.E.H., University of Algarve, Faro, Portugal.
出版信息
J Inorg Biochem. 2000 May 30;80(1-2):145-7. doi: 10.1016/s0162-0134(00)00022-2.
'Monovanadate' containing mainly monomeric, dimeric and tetrameric vanadate species or 'decavanadate', containing mainly decameric vanadate species inhibits the passive and the active efflux of Ca2+ through the sarcoplasmic reticulum calcium pump. When the efflux of Ca2+ by sarcoplasmic reticulum vesicles is not associated with ATP synthesis both vanadate solutions inhibit the passive efflux of Ca2+. However, only 'decavanadate' exerts noticeable effects when the efflux of Ca2+ is associated with ATP synthesis being the active efflux of Ca2+ almost completely inhibited by decameric species concentration as low as 40 microM.
主要包含单体、二聚体和四聚体钒酸盐物种的“偏钒酸盐”或主要包含十聚体钒酸盐物种的“十钒酸盐”可抑制钙离子通过肌浆网钙泵的被动和主动外流。当肌浆网囊泡介导的钙离子外流与ATP合成不相关时，两种钒酸盐溶液均可抑制钙离子的被动外流。然而，当钙离子外流与ATP合成相关（即钙离子的主动外流）时，只有“十钒酸盐”会产生显著影响，低至40微摩尔的十聚体物种浓度几乎可完全抑制钙离子的主动外流。
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