Kimelman D, Griffin K J
Department of Biochemistry, Center for Developmental Biology, University of Washington, Seattle 98195-7350, USA.
Curr Opin Genet Dev. 2000 Aug;10(4):350-6. doi: 10.1016/s0959-437x(00)00095-2.
Many of the key molecular events underlying the induction and patterning of the vertebrate mesoderm and endoderm have recently been elucidated. T-box transcription factors and TGF-beta and Wnt signaling pathways play crucial roles in the initial induction of the mesendoderm and the subdivision of the posterior mesoderm into rostral and caudal domains.
最近，许多脊椎动物中胚层和内胚层诱导及模式形成的关键分子事件已得到阐明。T-box转录因子、转化生长因子-β（TGF-β）和Wnt信号通路在中内胚层的初始诱导以及后中胚层分为头侧和尾侧区域的过程中发挥着关键作用。
