Golanov E V, Christensen J R, Reis D J
Department of Neurology and Neuroscience, Division of Neurobiology, Weill Medical College of Cornell University, 411 East 69th Street, KB 410, NY 10021, USA.
Neurosci Lett. 2000 Jul 21;288(3):183-6. doi: 10.1016/s0304-3940(00)01228-3.
We investigated whether the medullary cerebrovasodilator area (MCVA), a region of ventral medulla mediating elevations of regional cerebral blood flow (rCBF) and electroencephalogram (EEG) synchronization elicited in cerebral cortex from stimulation of reticulospinal neurons of rostral ventrolateral medulla (RVLM), also mediates comparable responses from the cerebellar fastigial nucleus (FN). In spinalized rats, electrical stimulation of MCVA, RVLM or FN elevated rCBF and synchronized the EEG. The FN-evoked responses were significantly attenuated or blocked by bilateral lesions of MCVA. The MCVA is a novel region of medullary reticular formation mediating actions of medullary and cerebellar centers on rCBF and EEG to link visceral centers of brainstem and cerebral cortex.
我们研究了延髓脑血管舒张区（MCVA），即延髓腹侧的一个区域，它介导了由刺激延髓头端腹外侧区（RVLM）的网状脊髓神经元所引起的大脑皮质局部脑血流量（rCBF）升高和脑电图（EEG）同步化，该区域是否也介导来自小脑顶核（FN）的类似反应。在脊髓横断的大鼠中，电刺激MCVA、RVLM或FN可使rCBF升高并使EEG同步化。FN诱发的反应在MCVA双侧受损时显著减弱或被阻断。MCVA是延髓网状结构的一个新区域，它介导延髓和小脑中枢对rCBF和EEG的作用，从而将脑干内脏中枢与大脑皮质联系起来。
